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    <loc>https://www.grekalab.org/anna-greka</loc>
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    <lastmod>2026-01-07</lastmod>
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    <lastmod>2022-03-12</lastmod>
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    <lastmod>2023-05-02</lastmod>
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      <image:caption>Guided by genetic mutations associated with the Rac1 pathway in a subset of kidney diseases, we uncovered a Rac1-TRPC5 feed-forward loop linking TRPC5 ion channel activity to cellular injury. Based on our discoveries, TRPC5 inhibitors are showing promising results in clinical trials.</image:caption>
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      <image:caption>Motivated to dissect the mechanisms by which mutations in the MUC1 gene lead to disease, we uncovered a cargo receptor pathway that handles the trafficking and degradation of misfolded secretory proteins. Targeting this pathway has led to exciting preclinical outcomes with therapeutic implications for many proteinopathies.</image:caption>
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    <lastmod>2024-12-18</lastmod>
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    <lastmod>2022-03-16</lastmod>
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